5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule compound that acts as a potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is an enzyme that regulates cellular metabolism and energy expenditure. By inhibiting NNMT, 5-Amino-1MQ can potentially increase NAD+ levels and enhance fat cell metabolism. Research has shown that NNMT is overexpressed in obesity and type 2 diabetes, making it an attractive target for metabolic disorders. In preclinical studies, NNMT inhibition led to reduced fat mass, improved glucose tolerance, and prevention of diet-induced obesity without affecting food intake.
| Research Status | Preclinical |
|---|---|
| Half-Life | Unknown |
| Administration | Oral |
| Typical Dosage | 50-150 mg oral |
| Molecular Weight | 173.21 Da |
| Molecular Formula | C10H11N2+ |
Inhibits nicotinamide N-methyltransferase (NNMT), increasing NAD+ levels and improving fat cell metabolism.
All information is presented for Research Use Only (RUO). Not medical advice.