5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule compound that acts as a potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is an enzyme that regulates cellular metabolism and energy expenditure. By inhibiting NNMT, 5-Amino-1MQ can potentially increase NAD+ levels and enhance fat cell metabolism. Research has shown that NNMT is overexpressed in obesity and type 2 diabetes, making it an attractive target for metabolic disorders. In preclinical studies, NNMT inhibition led to reduced fat mass, improved glucose tolerance, and prevention of diet-induced obesity without affecting food intake.
Key Data
Mechanism of Action
Inhibits nicotinamide N-methyltransferase (NNMT), increasing NAD+ levels and improving fat cell metabolism.
Reported Benefits
All information is presented for Research Use Only (RUO). Not medical advice.