Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) is a highly potent nootropic peptide derived from angiotensin IV. Developed at Washington State University, Dihexa is approximately 7 orders of magnitude more potent than BDNF (brain-derived neurotrophic factor) in promoting neuronal connectivity. The peptide works primarily through the hepatocyte growth factor (HGF)/c-Met receptor system, which is crucial for synaptogenesis, dendritic spine formation, and long-term memory consolidation. Dihexa is orally bioavailable and can cross the blood-brain barrier, making it particularly interesting for cognitive research. Studies have shown it can improve cognitive function in animal models of Alzheimer's disease and other conditions characterized by cognitive decline.
Key Data
Mechanism of Action
HGF/c-Met receptor system activation, promotes synaptogenesis and neuronal growth at picomolar concentrations.
Reported Benefits
All information is presented for Research Use Only (RUO). Not medical advice.