DIH
Synthetic peptide derived from angiotensin IV. A 2014 study of cultured hippocampal neurons and rodents, since retracted (2025), reported that dihexa promoted spinogenesis at picomolar concentrations. No human studies have been published.
Regulatory status (as of Sept 2026)
Not FDA-approved, no IND-stage human data published. Dihexa is slated for a PCAC review before the end of February 2027; PCAC output is advisory only and rulemaking would be required for any change.
See the FDA peptide regulatory tracker · Read our July 27, 2026 dispatch on the FDA PCAC peptide vote2 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content
Dihexa is a compound studied only in animals and lab experiments so far. Synthetic peptide derived from angiotensin IV.
| Half-life | Not established in published research |
|---|---|
| How it's given in studies | Oral or intraperitoneal (rodent studies only); no human administration published |
| Research stage | Preclinical (animal) |
| Dosing | Published research: No published human dosing detailsRodent and cell-culture work only: picomolar-to-nanomolar concentrations in hippocampal culture assays, and orally administered dihexa in rat models of cognitive impairment. No human dosing has been published.Community-reportedCommunity-reported: 10–40 mg oral, oral or subcutaneous |
Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.
Where each point comes from: Clinicalhuman trials and FDA labels Lab / animalrodent, cell and ex vivo studies Community-reporteduser experience and commonly used protocols, not from clinical studies
In plain terms: It is thought to boost a growth-factor system that helps nerve cells form connections, but the main study behind this was retracted. Proposed mechanism: activation of the hepatocyte growth factor (HGF)/c-Met system, promoting synaptogenesis at picomolar concentrations in cultured neurons. The main study proposing this mechanism (Benoist 2014, cultured neurons and rodents) was retracted in 2025; the other cited source is a narrative review of angiotensin IV analogue development (Wright 2015). No human studies have been published.
How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.
Community-reportedSome users report running Dihexa at 10–40 mg (oral or subcutaneous). This is not a recommendation.
Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.
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| Peptide | Half-Life | Route | Research Status |
|---|---|---|---|
| Dihexa | Unknown | Oral or intraperitoneal (rodent studies only); no human administration published | Preclinical (animal) |
| FGL (L) | Unknown | Subcutaneous injection | Preclinical (animal) |
| P21 | Unknown | Oral (mice) | Preclinical (animal) |
| PE-22-28 | No published PK data found | Subcutaneous injection, Intranasal | Preclinical (animal) |
| Pinealon | No published PK data found | Oral, Sublingual | Phase 1 / early human |
Values reflect figures reported in published research. Compare any peptides side-by-side →
This peptide belongs to the Cognitive category. View All Cognitive Peptides
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Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.