FGL(L) (also known as FG Loop peptide) is a synthetic 15-amino acid peptide derived from the second fibronectin type III domain of neural cell adhesion molecule (NCAM). The peptide mimics the function of NCAM in stimulating neuronal survival, neurite outgrowth, and synaptic plasticity. FGL works by binding to and activating the fibroblast growth factor receptor (FGFR), leading to downstream signaling through pathways including PLCγ, MAPK, and PI3K/Akt. Research has shown FGL enhances memory formation and has potential applications in conditions involving cognitive decline and neurodegenerative diseases. The peptide has demonstrated neuroprotective properties in various preclinical models.
| Research Status | Preclinical |
|---|---|
| Half-Life | Unknown |
| Administration | Subcutaneous injection |
| Typical Dosage | 1-2 mg |
| Molecular Weight | 1,678 Da |
| Molecular Formula | C71H116N20O26 |
Mimics NCAM cell adhesion molecule effects, promoting synaptic plasticity and neuronal communication.
All information is presented for Research Use Only (RUO). Not medical advice.