GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide and one of the first generation growth hormone secretagogues developed. It binds to the ghrelin receptor (GHS-R1a) to stimulate growth hormone release from the pituitary. GHRP-6 is notable for its potent appetite-stimulating effects, making it useful in research related to cachexia and wasting conditions. The peptide also has demonstrated cardioprotective properties in preclinical studies. GHRP-6 produces a strong GH pulse but is also associated with increased cortisol and prolactin release. It works synergistically with GHRH analogs to produce amplified growth hormone responses.
Key Data
Mechanism of Action
Ghrelin mimetic that stimulates GH release and significantly increases appetite through ghrelin pathway activation.
Reported Benefits
All information is presented for Research Use Only (RUO). Not medical advice.