Kisspeptin-10 is the shortest bioactive fragment of kisspeptin (metastin), a peptide encoded by the KISS1 gene that plays a critical role in the regulation of reproductive function. Kisspeptin neurons in the hypothalamus act upstream of GnRH neurons, providing essential stimulation for GnRH release and thus controlling the entire reproductive axis. The discovery of kisspeptin revolutionized understanding of puberty initiation and reproductive control. Kisspeptin-10 (the C-terminal 10 amino acids) retains full biological activity and potently stimulates LH and FSH release. It is being researched for infertility, IVF trigger protocols, and conditions involving hypothalamic dysfunction.
Key Data
Mechanism of Action
Activates GnRH neurons to stimulate pituitary release of LH and FSH.
Reported Benefits
All information is presented for Research Use Only (RUO). Not medical advice.