LL-37 (also known as CAP-18 or hCAP18) is a 37-amino acid human cathelicidin antimicrobial peptide that plays a crucial role in the innate immune system. It is the only cathelicidin found in humans and is produced by epithelial cells, macrophages, and neutrophils. LL-37 has broad-spectrum antimicrobial activity against bacteria, fungi, and enveloped viruses. Beyond direct antimicrobial effects, LL-37 modulates immune responses, promotes wound healing, induces angiogenesis, and has anti-biofilm properties. The peptide forms an alpha-helical structure in membrane environments, which is essential for its membrane-disrupting antimicrobial activity.
| Research Status | Preclinical |
|---|---|
| Half-Life | Unknown |
| Administration | Subcutaneous injection |
| Typical Dosage | 100-200 mcg |
| Molecular Weight | 4,493.3 Da |
| Molecular Formula | C205H340N60O53 |
Direct antimicrobial action, immune cell activation, wound healing promotion.
All information is presented for Research Use Only (RUO). Not medical advice.