LL-37 (also known as CAP-18 or hCAP18) is a 37-amino acid human cathelicidin antimicrobial peptide that plays a crucial role in the innate immune system. It is the only cathelicidin found in humans and is produced by epithelial cells, macrophages, and neutrophils. LL-37 has broad-spectrum antimicrobial activity against bacteria, fungi, and enveloped viruses. Beyond direct antimicrobial effects, LL-37 modulates immune responses, promotes wound healing, induces angiogenesis, and has anti-biofilm properties. The peptide forms an alpha-helical structure in membrane environments, which is essential for its membrane-disrupting antimicrobial activity.
Key Data
Mechanism of Action
Direct antimicrobial action, immune cell activation, wound healing promotion.
Reported Benefits
All information is presented for Research Use Only (RUO). Not medical advice.