Matrixyl (Palmitoyl Pentapeptide-4) (MAT)

Matrixyl (Palmitoyl Pentapeptide-4, also known as pal-KTTKS) is one of the most successful and widely used cosmetic peptides, developed by Sederma. The pentapeptide KTTKS was originally identified as a fragment of collagen type I propeptide — a natural signal (matrikine) produced during collagen turnover that tells fibroblasts to produce more collagen. Adding a palmitoyl (C-16 fatty acid) chain dramatically improved the peptide's skin penetration and stability. Clinical studies have shown that Matrixyl can reduce wrinkle depth by up to 44% over 4 months of twice-daily application.

Key Data

Research Status

Cosmetic Use

Half-Life

Topical (not systemically relevant)

Administration

Topical

Typical Dosage

2-5% in topical formulations

Molecular Weight

802.1 Da

Molecular Formula

C39H75N7O10

Mechanism of Action

Matrixyl mimics a collagen breakdown fragment (matrikine) that signals fibroblasts to increase production of collagen types I, III, and IV, fibronectin, elastin, and other extracellular matrix components. The palmitoyl chain enhances skin penetration.

Reported Benefits

• Stimulates collagen I and III synthesis
• Promotes extracellular matrix production
• Reduces fine lines and wrinkle depth
• Improves skin firmness and elasticity
• Enhances skin texture and smoothness
• Non-invasive anti-aging approach

All information is presented for Research Use Only (RUO). Not medical advice.