Reviewed by The Peptide Dispatch Editorial Team · Last reviewed July 6, 2026
Matrixyl (Palmitoyl Pentapeptide-4) (MAT) is a anti-aging peptide, at the cosmetic use stage in the published literature. Matrixyl (Palmitoyl Pentapeptide-4, also known as pal-KTTKS) is one of the most successful and widely used cosmetic peptides, developed by Sederma. The pentapeptide KTTKS was originally identified as a fragment of collagen type I propeptide — a natural signal (matrikine) produced during collagen turnover that tells fibroblasts to produce more collagen. Adding a palmitoyl (C-16 fatty acid) chain dramatically improved the peptide's skin penetration and stability. Clinical studies have shown that Matrixyl can reduce wrinkle depth by up to 44% over 4 months of twice-daily application.
Matrixyl (Palmitoyl Pentapeptide-4, also known as pal-KTTKS) is one of the most successful and widely used cosmetic peptides, developed by Sederma. The pentapeptide KTTKS was originally identified as a fragment of collagen type I propeptide — a natural signal (matrikine) produced during collagen turnover that tells fibroblasts to produce more collagen. Adding a palmitoyl (C-16 fatty acid) chain dramatically improved the peptide's skin penetration and stability. Clinical studies have shown that Matrixyl can reduce wrinkle depth by up to 44% over 4 months of twice-daily application.
| Research Status | Cosmetic Use |
|---|---|
| Half-Life | Topical (not systemically relevant) |
| Administration | Topical |
| Doses Reported in Published Studies | 2-5% in topical formulations |
| Molecular Weight | 802.1 Da |
| Molecular Formula | C39H75N7O10 |
Matrixyl mimics a collagen breakdown fragment (matrikine) that signals fibroblasts to increase production of collagen types I, III, and IV, fibronectin, elastin, and other extracellular matrix components. The palmitoyl chain enhances skin penetration.
Matrixyl (Palmitoyl Pentapeptide-4, also known as pal-KTTKS) is one of the most successful and widely used cosmetic peptides, developed by Sederma. The pentapeptide KTTKS was originally identified as a fragment of collagen type I propeptide — a natural signal (matrikine) produced during collagen turnover that tells…
Matrixyl mimics a collagen breakdown fragment (matrikine) that signals fibroblasts to increase production of collagen types I, III, and IV, fibronectin, elastin, and other extracellular matrix components. The palmitoyl chain enhances skin penetration.
Matrixyl (Palmitoyl Pentapeptide-4) is at the following stage in the published literature: Cosmetic Use. All information is for research and educational purposes only.
Reported half-life: Topical (not systemically relevant).
Reported administration route in the literature: Topical. This is not a recommendation for human use.
Educational content, not medical advice. Effects described are drawn from cited research in study subjects.