MGF (Mechano Growth Factor) is a splice variant of IGF-1 (insulin-like growth factor 1) that is expressed specifically in response to mechanical stress and muscle damage. While standard IGF-1 (IGF-1Ea) is produced primarily by the liver and acts systemically, MGF is produced locally in muscle tissue and has a distinct C-terminal E-peptide sequence. MGF plays a crucial role in muscle repair by activating satellite cells (muscle stem cells) and promoting their proliferation before differentiation. This mechano-sensitive expression makes MGF particularly important in muscle adaptation to exercise and recovery from injury.
Key Data
Mechanism of Action
Activates muscle satellite cells and promotes local muscle repair independent of systemic IGF-1.
Reported Benefits
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