MGF
Splice variant of IGF-1 produced in response to mechanical stress. Activation of satellite cells independent of systemic IGF-1 is a mechanism proposed from rodent and expression studies, not an established effect of injected peptide.
Regulatory status (as of Sept 2026)
Not FDA-approved. PEG-MGF is slated for a PCAC review before the end of February 2027; unmodified MGF was not among the April 2026 503A Category 2 removals or the July 2026 votes.
See the FDA peptide regulatory tracker · Read our July 27, 2026 dispatch on the FDA PCAC peptide vote3 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content
MGF (Mechano Growth Factor) is a compound studied only in animals and lab experiments so far. Splice variant of IGF-1 produced in response to mechanical stress.
| Half-life | Not established in published research |
|---|---|
| How it's given in studies | Intramuscular (site-specific) |
| Research stage | Preclinical (animal) |
| Dosing | Published research: No published human dosing detailsDirect MGF injection into contused skeletal muscle in a mouse macrophage-depletion model; MGF loaded into mesoporous-silica/carbon-nanotube coatings on titanium scaffolds in animal implant models; endogenous MGF expression measured in rat immobilisation/vibration studies. No human dosing published.Community-reportedCommunity-reported: 100–200 mcg (site-specific), intramuscular (site-specific) |
Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.
Where each point comes from: Clinicalhuman trials and FDA labels Lab / animalrodent, cell and ex vivo studies Community-reporteduser experience and commonly used protocols, not from clinical studies
In plain terms: It is a version of IGF-1 that muscles make under strain; it is thought to help muscle repair, but a mouse study did not confirm better regrowth. Proposed mechanism, from animal studies: an IGF-1 splice variant (IGF1Ec) proposed to activate muscle satellite cells and support local muscle repair. In a mouse muscle-contusion model, MGF injection did not improve muscle-fiber regeneration but reduced fibrosis and inflammatory markers (Liu 2019).
How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.
Community-reportedCommonly reported doses range from 100 to 200 mcg — intramuscular (site-specific). This is not a recommendation.
Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.
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| Peptide | Half-Life | Route | Research Status |
|---|---|---|---|
| MGF (Mechano Growth Factor) | No published PK data found | Intramuscular (site-specific) | Preclinical (animal) |
| ACE-031 | ~12 days | Subcutaneous injection | Discontinued |
| Follistatin 344 | Unknown | Subcutaneous injection | Preclinical (animal) |
| IGF-1 DES | No published PK data found (des(1-3)IGF-I clears more rapidly than IGF-I in pigs/marmosets, but no published t1/2 value was found) | Intramuscular (site-specific) | Preclinical (animal) |
| IGF-1 LR3 | No published PK data found | Subcutaneous or intramuscular | Preclinical (animal) |
Values reflect figures reported in published research. Compare any peptides side-by-side →
This peptide belongs to the Muscle category. View All Muscle Peptides
Healing, Growth Hormone
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Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.