MGF (Mechano Growth Factor) is a splice variant of IGF-1 (insulin-like growth factor 1) that is expressed specifically in response to mechanical stress and muscle damage. While standard IGF-1 (IGF-1Ea) is produced primarily by the liver and acts systemically, MGF is produced locally in muscle tissue and has a distinct C-terminal E-peptide sequence. MGF plays a crucial role in muscle repair by activating satellite cells (muscle stem cells) and promoting their proliferation before differentiation. This mechano-sensitive expression makes MGF particularly important in muscle adaptation to exercise and recovery from injury.
| Research Status | Research chemical |
|---|---|
| Half-Life | 5-7 minutes |
| Administration | Intramuscular (site-specific) |
| Typical Dosage | 100-200 mcg (site-specific) |
| Molecular Weight | Approximately 2,867 Da (E-peptide) |
| Molecular Formula | C123H200N42O37S |
Activates muscle satellite cells and promotes local muscle repair independent of systemic IGF-1.
All information is presented for Research Use Only (RUO). Not medical advice.