MK677
Orally active, non-peptide small-molecule growth hormone secretagogue that mimics ghrelin, providing 24-hour GH elevation without injections.
Regulatory status (as of Sept 2026)
Not FDA-approved. Not a peptide; not eligible for 503A peptide bulks lists as a peptide. WADA-prohibited (GH secretagogue).
See the FDA peptide regulatory tracker · Read our July 27, 2026 dispatch on the FDA PCAC peptide vote3 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content
MK-677 (Ibutamoren) is an investigational compound tested in mid-stage (phase 2) human trials. Orally active, non-peptide small-molecule growth hormone secretagogue that mimics ghrelin, providing 24-hour GH elevation without injections.
| Half-life | Not established in published research |
|---|---|
| How it's given in studies | Oral |
| Research stage | Phase 2 |
| Dosing | Published research: 25 mg oral daily details25 mg oral daily (healthy older adults 2-yr RCT n=65; AD RCT n=563; hip-fracture Phase 2b n=123; obese men).Community-reportedCommunity-reported: 10–25 mg oral, oral |
Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.
Where each point comes from: Clinicalhuman trials and FDA labels Lab / animalrodent, cell and ex vivo studies Community-reporteduser experience and commonly used protocols, not from clinical studies
In plain terms: It is a pill that acts like the hunger hormone ghrelin and raised growth hormone and IGF-1 levels in a clinical trial. Orally active, non-peptide ghrelin mimetic. In a 2-year RCT in healthy older adults, daily MK-677 increased GH and IGF-I levels to those of healthy young adults (Nass 2008).
How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.
Community-reportedUsers have reported doses of 10–25 mg (oral). This is not a recommendation.
Side effects reported in studies are listed separately below.
Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.
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| Peptide | Half-Life | Route | Research Status |
|---|---|---|---|
| MK-677 (Ibutamoren) | No published PK data found | Oral | Phase 2 |
| CJC-1295 (no DAC) | No published PK data found | Subcutaneous injection | Preclinical (animal) |
| CJC-1295 (with DAC) | 6-8 days | Subcutaneous injection | Phase 1 / early human |
| GHRP-2 | No published PK data found | Subcutaneous injection | Phase 1 / early human |
| GHRP-6 | No published PK data found | Subcutaneous injection | Phase 1 / early human |
Values reflect figures reported in published research. Compare any peptides side-by-side →
This peptide belongs to the Growth Hormone category. View All Growth Hormone Peptides
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Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.