MK-677 (Ibutamoren) is an orally active, non-peptide growth hormone secretagogue that mimics the action of ghrelin at the GHS-R1a receptor. Unlike injectable peptide GH secretagogues, MK-677 is effective when taken orally and has a long duration of action (approximately 24 hours). The compound produces sustained elevation of GH and IGF-1 levels without significantly affecting cortisol levels. MK-677 has been extensively studied in clinical trials for various conditions including growth hormone deficiency, muscle wasting, osteoporosis, and age-related frailty. Its oral bioavailability and once-daily dosing make it convenient for long-term research protocols.
Key Data
Mechanism of Action
Non-peptide ghrelin mimetic that activates ghrelin receptors orally, causing sustained GH and IGF-1 elevation.
Reported Benefits
All information is presented for Research Use Only (RUO). Not medical advice.