MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a mitochondria-derived peptide (MDP) encoded within the mitochondrial genome. Discovered in 2015, MOTS-c is a 16-amino acid peptide that plays a significant role in metabolic regulation and exercise physiology. The peptide enhances insulin sensitivity, promotes glucose uptake, and activates the AMPK pathway. MOTS-c is released from mitochondria and can act in an endocrine manner, affecting distant tissues. Levels of MOTS-c decline with age and are lower in individuals with type 2 diabetes and metabolic syndrome. Exercise increases circulating MOTS-c levels, suggesting it mediates some beneficial effects of physical activity.
| Research Status | Preclinical |
|---|---|
| Half-Life | Unknown |
| Administration | Subcutaneous injection |
| Typical Dosage | 5-10 mg weekly |
| Molecular Weight | 2,174 Da |
| Molecular Formula | C100H152N28O23S2 |
Activates AMPK pathway, improves glucose regulation, enhances mitochondrial function and metabolic flexibility.
All information is presented for Research Use Only (RUO). Not medical advice.