MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a mitochondria-derived peptide (MDP) encoded within the mitochondrial genome. Discovered in 2015, MOTS-c is a 16-amino acid peptide that plays a significant role in metabolic regulation and exercise physiology. The peptide enhances insulin sensitivity, promotes glucose uptake, and activates the AMPK pathway. MOTS-c is released from mitochondria and can act in an endocrine manner, affecting distant tissues. Levels of MOTS-c decline with age and are lower in individuals with type 2 diabetes and metabolic syndrome. Exercise increases circulating MOTS-c levels, suggesting it mediates some beneficial effects of physical activity.
Key Data
Mechanism of Action
Activates AMPK pathway, improves glucose regulation, enhances mitochondrial function and metabolic flexibility.
Reported Benefits
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