MOTSC
Mitochondria-derived peptide that regulates metabolic homeostasis; in mice it prevented diet-induced obesity and insulin resistance.
Regulatory status (as of Sept 2026)
Not FDA-approved. Removed from 503A Category 2 on April 15, 2026. PCAC recommended for the 503A Bulks List (advisory); awaiting FDA rulemaking; not lawfully compoundable under 503A as of Sept 17, 2026. PCAC vote: 7–5–2 (yes–no–abstain), July 23, 2026.
See the FDA peptide regulatory tracker · Read our July 27, 2026 dispatch on the FDA PCAC peptide vote2 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content
MOTS-c is a compound studied only in animals and lab experiments so far. Mitochondria-derived peptide that regulates metabolic homeostasis; in mice it prevented diet-induced obesity and insulin resistance.
| Half-life | Not established in published research |
|---|---|
| How it's given in studies | Subcutaneous injection |
| Research stage | Preclinical (animal) |
| Dosing | Published research: No published human dosing detailsi.p. injection in mice fed high-fat diet and aged mice (Lee et al. 2015); exact mg/kg in full text, not in abstractCommunity-reportedCommunity-reported: 5–10 mg weekly, subcutaneous injection |
Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.
Where each point comes from: Clinicalhuman trials and FDA labels Lab / animalrodent, cell and ex vivo studies Community-reporteduser experience and commonly used protocols, not from clinical studies
In plain terms: It is a small peptide made by mitochondria that acts mainly on muscle energy use, based on mouse and cell studies. Proposed mechanism, from mouse and cell studies (Lee 2015): a mitochondrial-derived peptide whose primary target appears to be skeletal muscle; it inhibits the folate cycle and de novo purine biosynthesis, leading to AMPK activation. In mice it prevented age-dependent and high-fat-diet-induced insulin resistance and diet-induced obesity.
How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.
Community-reportedSome users report running MOTS-c at 5–10 mg weekly (subcutaneous injection). This is not a recommendation.
Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.
New research, FDA peptide updates, and what users are reporting. One email a week. Unsubscribe anytime.
| Peptide | Half-Life | Route | Research Status |
|---|---|---|---|
| MOTS-c | Unknown | Subcutaneous injection | Preclinical (animal) |
| 5-Amino-1MQ | Unknown | Oral | Preclinical (animal) |
| AOD-9604 | No published PK data found | Subcutaneous injection | Discontinued |
| Adipotide (FTPP) | No published PK data found | Subcutaneous injection | Preclinical (animal) |
| Dulaglutide | ~5 days | Subcutaneous injection | FDA-approved |
Values reflect figures reported in published research. Compare any peptides side-by-side →
This peptide belongs to the Metabolic category. View All Metabolic Peptides
Anti-Aging
From Our Affiliated Clinic
1836 Wellness is a physician-supervised clinic in Houston, TX. Discussing a compound on this page is not an offer to prescribe or supply it.
See how it works →Disclosure: The Peptide Dispatch and 1836 Wellness are commonly owned by 1836 Wellness LLC. We may benefit financially if you become a client of 1836 Wellness. Learn more.
Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.