SEMA
GLP-1 receptor agonist FDA-approved for type 2 diabetes and chronic weight management. Brand names include Ozempic and Wegovy. Semaglutide is a prescription-only medication and must be obtained and used under the supervision of a licensed healthcare provider.
Regulatory status (as of Sept 2026)
FDA-approved. Semaglutide is no longer on the FDA shortage list, so 503A/503B compounding of copies is restricted.
See the FDA peptide regulatory tracker · Read our July 27, 2026 dispatch on the FDA PCAC peptide vote2 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content
Semaglutide is an FDA-approved prescription drug. GLP-1 receptor agonist FDA-approved for type 2 diabetes and chronic weight management.
| Half-life | About 7 days |
|---|---|
| How it's given in studies | Subcutaneous injection |
| Research stage | FDA-approved |
| Dosing | Published research: Humans: 2.4 mg subcutaneous once weekly for 68 weeks, n=1961 detailsHumans: 2.4 mg s.c. once weekly for 68 weeks, n=1961 (STEP 1, Wilding 2021). 0.5-1.0 mg s.c. weekly in healthy Japanese and Caucasian men (2018 PK trial).Community-reportedCommunity-reported: 0.25–2.4 mg weekly, subcutaneous injection |
Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.
Where each point comes from: Clinicalhuman trials and FDA labels Lab / animalrodent, cell and ex vivo studies Community-reporteduser experience and commonly used protocols, not from clinical studies
In plain terms: It copies the gut hormone GLP-1, which is described as reducing appetite and slowing how fast the stomach empties. Proposed mechanism (GLP-1 receptor agonist pharmacology): GLP-1 receptor activation is described as reducing appetite and slowing gastric emptying. Its effect on body weight comes from clinical trials: in the STEP 1 phase 3 RCT in adults with overweight or obesity, once-weekly semaglutide 2.4 mg with lifestyle intervention produced a mean weight change of -14.9% at 68 weeks vs -2.4% with placebo (Wilding 2021).
How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.
Community-reportedCommonly reported doses range from 0.25 to 2.4 mg weekly (subcutaneous injection). This is not a recommendation.
Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.
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| Peptide | Half-Life | Route | Research Status |
|---|---|---|---|
| Semaglutide | ~7 days | Subcutaneous injection | FDA-approved |
| 5-Amino-1MQ | Unknown | Oral | Preclinical (animal) |
| AOD-9604 | No published PK data found | Subcutaneous injection | Discontinued |
| Adipotide (FTPP) | No published PK data found | Subcutaneous injection | Preclinical (animal) |
| Dulaglutide | ~5 days | Subcutaneous injection | FDA-approved |
Values reflect figures reported in published research. Compare any peptides side-by-side →
This peptide belongs to the Metabolic category. View All Metabolic Peptides
From Our Affiliated Clinic
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Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.