SS-31 (also known as Elamipretide, Bendavia, or MTP-131) is a cell-permeable tetrapeptide that selectively targets and concentrates in the inner mitochondrial membrane. The peptide binds to cardiolipin, a phospholipid essential for the structure and function of the electron transport chain, particularly at Complex III and Complex IV. By stabilizing cardiolipin, SS-31 optimizes mitochondrial cristae structure, enhances ATP production, and reduces the generation of reactive oxygen species at their source. This mitochondria-targeted approach addresses the fundamental role of mitochondrial dysfunction in aging and numerous age-related diseases. SS-31 has been evaluated in clinical trials for heart failure, primary mitochondrial myopathy, and other conditions characterized by mitochondrial dysfunction.
Key Data
Mechanism of Action
Targets cardiolipin in mitochondrial inner membrane, stabilizing electron transport and reducing ROS production.
Reported Benefits
All information is presented for Research Use Only (RUO). Not medical advice.