SS-31 (also known as Elamipretide, Bendavia, or MTP-131) is a cell-permeable tetrapeptide that selectively targets and concentrates in the inner mitochondrial membrane. The peptide binds to cardiolipin, a phospholipid essential for the structure and function of the electron transport chain, particularly at Complex III and Complex IV. By stabilizing cardiolipin, SS-31 optimizes mitochondrial cristae structure, enhances ATP production, and reduces the generation of reactive oxygen species at their source. This mitochondria-targeted approach addresses the fundamental role of mitochondrial dysfunction in aging and numerous age-related diseases. SS-31 has been evaluated in clinical trials for heart failure, primary mitochondrial myopathy, and other conditions characterized by mitochondrial dysfunction.
| Research Status | Clinical trials |
|---|---|
| Half-Life | ~1 hour |
| Administration | Subcutaneous or IV injection |
| Typical Dosage | 0.25-4 mg/kg |
| Molecular Weight | 639.8 Da |
| Molecular Formula | C32H49N9O5 |
Targets cardiolipin in mitochondrial inner membrane, stabilizing electron transport and reducing ROS production.
All information is presented for Research Use Only (RUO). Not medical advice.