TB-500 (TB5)

Healing Preclinical

TB-500 is a synthetic version of the naturally occurring 43-amino acid peptide Thymosin Beta-4 (Tβ4). This peptide is found in virtually all human and animal cells and plays a fundamental role in building new blood vessels, new muscle tissue fibers, and promoting cell migration and differentiation. TB-500 is the primary regulator of actin, a cell-building protein essential for healing and cell migration. Its unique molecular structure allows it to travel long distances through tissues, which explains its systemic healing properties. The peptide has been extensively studied in animal models for wound healing, cardiac protection, and tissue regeneration applications. Unlike many peptides that act locally, TB-500 can affect tissues throughout the body due to its ability to regulate actin systemically, making it particularly interesting for research into whole-body healing responses.

Key Data

Research Status
Preclinical
Half-Life
2-3 days
Administration
Subcutaneous injection
Typical Dosage
2-5 mg per week
Molecular Weight
4,982 Da (full peptide) | Active fragment LKKTETQ: 846.97 g/mol
Molecular Formula
C212H350N56O78S (full) | Active fragment: C36H66N10O13

Mechanism of Action

Promotes cell migration and differentiation, upregulates actin, reduces inflammation through multiple pathways.

Reported Benefits

All information is presented for Research Use Only (RUO). Not medical advice.

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