Reviewed by The Peptide Dispatch Editorial Team · Last reviewed July 6, 2026
TB-500 (TB5) is a healing peptide, at the preclinical stage in the published literature. TB-500 is a synthetic version of the naturally occurring 43-amino acid peptide Thymosin Beta-4 (Tβ4). This peptide is found in virtually all human and animal cells and plays a fundamental role in building new blood vessels, new muscle tissue fibers, and promoting cell migration and differentiation. TB-500 is the primary regulator of actin, a cell-building protein essential for healing and cell migration. Its unique molecular structure allows it to travel long distances through tissues, which explains its systemic healing properties. The peptide has been extensively studied in animal models for wound healing, cardiac protection, and tissue regeneration applications. Unlike many peptides that act locally, TB-500 can affect tissues throughout the body due to its ability to regulate actin systemically, making it particularly interesting for research into whole-body healing responses.
TB-500 is a synthetic version of the naturally occurring 43-amino acid peptide Thymosin Beta-4 (Tβ4). This peptide is found in virtually all human and animal cells and plays a fundamental role in building new blood vessels, new muscle tissue fibers, and promoting cell migration and differentiation. TB-500 is the primary regulator of actin, a cell-building protein essential for healing and cell migration. Its unique molecular structure allows it to travel long distances through tissues, which explains its systemic healing properties. The peptide has been extensively studied in animal models for wound healing, cardiac protection, and tissue regeneration applications. Unlike many peptides that act locally, TB-500 can affect tissues throughout the body due to its ability to regulate actin systemically, making it particularly interesting for research into whole-body healing responses.
| Research Status | Preclinical |
|---|---|
| Half-Life | 2-3 days |
| Administration | Subcutaneous injection |
| Doses Reported in Published Studies | 2-5 mg per week |
| Molecular Weight | 4,982 Da (full peptide) | Active fragment LKKTETQ: 846.97 g/mol |
| Molecular Formula | C212H350N56O78S (full) | Active fragment: C36H66N10O13 |
Promotes cell migration and differentiation, upregulates actin, reduces inflammation through multiple pathways.
TB-500 is a synthetic version of the naturally occurring 43-amino acid peptide Thymosin Beta-4 (Tβ4). This peptide is found in virtually all human and animal cells and plays a fundamental role in building new blood vessels, new muscle tissue fibers, and promoting cell migration and differentiation. TB-500 is the…
Promotes cell migration and differentiation, upregulates actin, reduces inflammation through multiple pathways.
TB-500 is at the following stage in the published literature: Preclinical. All information is for research and educational purposes only.
Reported half-life: 2-3 days.
Reported administration route in the literature: Subcutaneous injection. This is not a recommendation for human use.
Educational content, not medical advice. Effects described are drawn from cited research in study subjects.