AOD

AOD-9604

Metabolic Growth Hormone Discontinued

Fragment of human growth hormone (amino acids 176-191) studied for obesity in early-phase human trials; weight-loss efficacy was not established in published literature. Sponsor and preclinical data describe it as lacking the growth-promoting (IGF-1-raising) effects of HGH; no published human study found confirms this.

Regulatory status (as of Sept 2026)

Not FDA-approved. Listed as a prohibited substance in WADA doping-control screening (PMID 26578461, 25208511).

See the FDA peptide regulatory tracker · Read our July 27, 2026 dispatch on the FDA PCAC peptide vote
Educational summary. Every effect described below is drawn from the cited published research and describes what was observed in research subjects — not a promise of results, a dose recommendation, or an endorsement for human use. Many peptides are not FDA-approved. Consult a licensed healthcare provider before making any health decision. Full disclaimer.

3 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content

TL;DR — AOD-9604 at a Glance

AOD-9604 is a compound whose development or US marketing has been discontinued. Fragment of human growth hormone (amino acids 176-191) studied for obesity in early-phase human trials; weight-loss efficacy was not established in published literature.

Half-lifeNot established in published research
How it's given in studiesSubcutaneous injection
Research stageDiscontinued
Dosing
Published research: No published human dosing
detailsRabbit OA model: 0.25 mg intra-articular weekly (Kwon 2015). No PubMed-indexed human dose-ranging paper was found.
Community-reportedCommunity-reported: 250–500 mcg, subcutaneous injection

Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.

Where each point comes from: Clinicalhuman trials and FDA labels   Lab / animalrodent, cell and ex vivo studies   Community-reporteduser experience and commonly used protocols, not from clinical studies

How It Works

In plain terms: It is a piece of growth hormone that is said to help break down fat without growth hormone's other effects, but no published human study confirms this. Proposed mechanism, not confirmed in a published human study: a modified C-terminal fragment of human growth hormone (amino acids 177-191 with an added N-terminal tyrosine) that is reported to mimic the lipolytic (fat-breakdown) properties of growth hormone without its diabetogenic effects (as described by Cox 2015). Sponsor and preclinical data describe it as not raising IGF-1.

Effects Reported in Research

How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.

  • ClinicalStudied for obesity in early-phase human trials; weight-loss efficacy was not established in published literature.
  • Lab / animalNo IGF-1 increase reported in sponsor/preclinical data; no published human study found confirms this.
  • Lab / animalIntra-articular AOD9604 improved cartilage scores in a rabbit collagenase-OA model (Kwon 2015).

What Users Report (Community, Not Clinical)

Commonly reported protocol

Community-reportedCommonly reported doses range from 250 to 500 mcg (subcutaneous injection). This is not a recommendation.

What users report

  • Community-reportedFat metabolism
  • Community-reportedWeight management — Research note: the published study did not confirm this (early-phase human trials did not establish weight-loss efficacy).

Side effects users report

  • Community-reportedHeadache (rare)

Side effects reported in studies are listed separately below.

Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.

Side Effects and Safety Notes

  • Injection site reactions (anecdotal)
  • Human safety data are limited; no peer-reviewed human safety publication found

References

  1. AOD-9604 Metabolic
    Wilding J. Current opinion in investigational drugs (London, England : 2000). 2004. PMID: 15134286.
    Study type: Drug-development review.
    PubMed
  2. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model
    Kwon DR, Park GY. Annals of clinical and laboratory science. 2015. PMID: 26275694.
    Study type: Rabbit OA model, n=32.
    PubMed
  3. Detection and in vitro metabolism of AOD9604
    Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D. Drug testing and analysis. 2015. PMID: 25208511.
    Study type: Analytical / in vitro metabolism.
    DOI: 10.1002/dta.1715 · PubMed

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How AOD-9604 Compares

PeptideHalf-LifeRouteResearch Status
AOD-9604No published PK data foundSubcutaneous injectionDiscontinued
5-Amino-1MQUnknownOralPreclinical (animal)
Adipotide (FTPP)No published PK data foundSubcutaneous injectionPreclinical (animal)
Dulaglutide~5 daysSubcutaneous injectionFDA-approved
Exenatide2.4 hours (immediate-release)Subcutaneous injectionFDA-approved

Values reflect figures reported in published research. Compare any peptides side-by-side →

Frequently Asked Questions

What is AOD-9604?
Fragment of human growth hormone (amino acids 176-191) studied for obesity in early-phase human trials; weight-loss efficacy was not established in published literature. Sponsor and preclinical data describe it as lacking the growth-promoting (IGF-1-raising) effects of HGH; no published human study found confirms this.
How does AOD-9604 work?
In plain terms: It is a piece of growth hormone that is said to help break down fat without growth hormone's other effects, but no published human study confirms this. Proposed mechanism, not confirmed in a published human study: a modified C-terminal fragment of human growth hormone (amino acids 177-191 with an added N-terminal tyrosine) that is reported to mimic the lipolytic (fat-breakdown) properties of growth hormone without its diabetogenic effects (as described by Cox 2015). Sponsor and preclinical data describe it as not raising IGF-1.
What is the research status of AOD-9604?
AOD-9604 is at the following stage in the published literature: Discontinued. All information is for research and educational purposes only.
What is the half-life of AOD-9604?
Reported half-life: No published PK data found.
How is AOD-9604 administered in research?
Reported administration route in the literature: Subcutaneous injection. This is not a recommendation for human use.

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Category

This peptide belongs to the Metabolic category. View All Metabolic Peptides

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Growth Hormone

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Sources & Methodology

Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.

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