THYM

Thymalin

Immune Approved outside US

Bovine thymus extract containing multiple thymic peptides including thymulin. Used in Russia for immune modulation.

Regulatory status (as of Sept 2026)

Not FDA-approved; not available as a US drug.

See the FDA peptide regulatory tracker · Read our July 27, 2026 dispatch on the FDA PCAC peptide vote
Educational summary. Every effect described below is drawn from the cited published research and describes what was observed in research subjects — not a promise of results, a dose recommendation, or an endorsement for human use. Many peptides are not FDA-approved. Consult a licensed healthcare provider before making any health decision. Full disclaimer.

3 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content

TL;DR — Thymalin at a Glance

Thymalin is approved as a medicine in some countries outside the US, but not by the FDA. Bovine thymus extract containing multiple thymic peptides including thymulin.

Half-lifeNot established in published research
How it's given in studiesIntramuscular injection
Research stageApproved outside US
Dosing
Published research: No PubMed-indexed dosing study found
detailsNo PubMed-indexed dosing study found; Russian clinical use (e.g., COVID-19 adjunct studies) does not report dose in abstracts.
Community-reportedCommunity-reported: 10 mg daily, intramuscular injection

Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.

Where each point comes from: Clinicalhuman trials and FDA labels   Lab / animalrodent, cell and ex vivo studies   Community-reporteduser experience and commonly used protocols, not from clinical studies

How It Works

In plain terms: It is an extract of thymus gland peptides thought to support the immune system. Proposed mechanism: an immunomodulatory polypeptide extract of thymus. Its proposed actions include influencing the differentiation of human hematopoietic stem cells (Khavinson 2021) and, for its KE and EW dipeptide components, effects on gene expression in vitro (Linkova 2023).

Effects Reported in Research

How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.

  • ClinicalRussian clinical reports in COVID-19 (non-blinded) described faster normalization of inflammatory markers and lower mortality; not independently replicated.

What Users Report (Community, Not Clinical)

Commonly reported protocol

Community-reportedUsers have reported 10 mg daily (intramuscular injection). This is not a recommendation.

What users report

  • Community-reportedImmune restoration
  • Community-reportedThymus regeneration
  • Community-reportedAnti-aging
  • Community-reportedInfection resistance

Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.

Side Effects and Safety Notes

  • Human safety data in Western literature are limited
  • Allergic reactions possible (bovine extract)

References

  1. Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19
    Khavinson VK, Kuznik BI, Trofimova SV, Volchkov VA, Rukavishnikova SA, Titova ON et al. Stem cell reviews and reports. 2021. PMID: 33575961.
    Study type: Clinical comparison, COVID-19 (Russia).
    DOI: 10.1007/s12015-020-10087-6 · PubMed
  2. [Morphological compound and indicators of the blood clotting system in severe COVID-19 patients of middle aged and elderly during treatment of Tocilizumab and Thymalin.]
    Kuznik BI, Shapovalov KG, Smolyakov YN, Lukyanov SA, Tereshkov PP, Kazantseva LS et al. Advances in gerontology = Uspekhi gerontologii. 2022. PMID: 36169363.
    Study type: Non-randomized clinical comparison.
    PubMed
  3. The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19
    Linkova N, Khavinson V, Diatlova A, Petukhov M, Vladimirova E, Sukhareva M et al. International journal of molecular sciences. 2023. PMID: 37686182.
    Study type: In vitro.
    DOI: 10.3390/ijms241713377 · PubMed

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How Thymalin Compares

PeptideHalf-LifeRouteResearch Status
ThymalinNo published PK data foundIntramuscular injectionApproved outside US
KPVNo published PK data foundSubcutaneous injection, Oral, TopicalPreclinical (animal)
LL-37UnknownSubcutaneous injectionPhase 2
Thymopoietin II Fragment (TP-1)UnknownSubcutaneous injectionPreclinical (animal)
Thymosin Alpha-1No published human PK data found; ~3 h for native Tα1 in rats (Shen 2019). Literature describes a 'short plasma half-life' requiring twice-weekly s.c. dosing.Subcutaneous injectionApproved outside US

Values reflect figures reported in published research. Compare any peptides side-by-side →

Frequently Asked Questions

What is Thymalin?
Bovine thymus extract containing multiple thymic peptides including thymulin. Used in Russia for immune modulation.
How does Thymalin work?
In plain terms: It is an extract of thymus gland peptides thought to support the immune system. Proposed mechanism: an immunomodulatory polypeptide extract of thymus. Its proposed actions include influencing the differentiation of human hematopoietic stem cells (Khavinson 2021) and, for its KE and EW dipeptide components, effects on gene expression in vitro (Linkova 2023).
What is the research status of Thymalin?
Thymalin is at the following stage in the published literature: Approved outside US. All information is for research and educational purposes only.
What is the half-life of Thymalin?
Reported half-life: No published PK data found.
How is Thymalin administered in research?
Reported administration route in the literature: Intramuscular injection. This is not a recommendation for human use.

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Category

This peptide belongs to the Immune category. View All Immune Peptides

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Sources & Methodology

Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.

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