CJC

CJC-1295 (no DAC)

Growth Hormone Preclinical (animal)

Modified Growth Hormone Releasing Factor (1-29), proposed to provide more stable GH release when combined with GHRPs (no primary study found). Also known as Mod GRF 1-29.

Educational summary. Every effect described below is drawn from the cited published research and describes what was observed in research subjects — not a promise of results, a dose recommendation, or an endorsement for human use. Many peptides are not FDA-approved. Consult a licensed healthcare provider before making any health decision. Full disclaimer.

2 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content

TL;DR — CJC-1295 (no DAC) at a Glance

CJC-1295 (no DAC) is a compound studied only in animals and lab experiments so far. Modified Growth Hormone Releasing Factor (1-29), proposed to provide more stable GH release when combined with GHRPs (no primary study found).

Half-lifeNot established in published research
How it's given in studiesSubcutaneous injection
Research stagePreclinical (animal)
Dosing
Published research: No published studies of Mod GRF(1-29)/CJC-1295 no DAC found
detailsNo published studies of Mod GRF(1-29)/CJC-1295 no DAC found. CJC-1295 with DAC: 30 or 60 µg/kg s.c. single/weekly doses in healthy adults. Sermorelin: 1 µg/kg i.v. as a diagnostic GH stimulation test in children.
Community-reportedCommunity-reported: 100–200 mcg, subcutaneous injection

Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.

Where each point comes from: Clinicalhuman trials and FDA labels   Lab / animalrodent, cell and ex vivo studies   Community-reporteduser experience and commonly used protocols, not from clinical studies

How It Works

In plain terms: It is expected to prompt the pituitary gland to release growth hormone, based on similar compounds; it has not been studied directly. Proposed mechanism, inferred from related GHRH analogues (no published studies of this compound were found): a GHRH-receptor agonist expected to stimulate pituitary GH release. The related GHRH analogue sermorelin (GRF 1-29) stimulates GH secretion from the anterior pituitary (Prakash 1999).

Effects Reported in Research

How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.

  • Lab / animalIn animal studies: enhanced GH release
  • Body composition, recovery, sleep and anti-aging effects are hypothesized based on GHRH pharmacology; no published studies of this compound

What Users Report (Community, Not Clinical)

Commonly reported protocol

Community-reportedIn user communities, CJC-1295 (no DAC) is typically run at 100–200 mcg (subcutaneous injection). This is not a recommendation.

What users report

  • Community-reportedImproved body composition
  • Community-reportedEnhanced recovery
  • Community-reportedBetter sleep
  • Community-reportedAnti-aging effects

Side effects users report

  • Community-reportedFlushing
  • Community-reportedHeadache
  • Community-reportedDizziness
  • Community-reportedInjection site reaction

Side effects reported in studies are listed separately below.

Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.

Side Effects and Safety Notes

  • No published human safety data for the no-DAC form
  • ClinicalFor CJC-1295 with DAC: injection-site reactions and no serious adverse events in 28-49 day trials (PMID 16352683)

References

  1. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
    Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. The Journal of clinical endocrinology and metabolism. 2006. PMID: 16352683.
    Study type: Two randomized placebo-controlled ascending-dose trials in healthy adults (DAC form).
    DOI: 10.1210/jc.2005-1536 · PubMed
  2. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency
    Prakash A, Goa KL. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 1999. PMID: 18031173.
    Study type: Drug review (GRF 1-29 analog).
    DOI: 10.2165/00063030-199912020-00007 · PubMed

Get the weekly Dispatch

New research, FDA peptide updates, and what users are reporting. One email a week. Unsubscribe anytime.

How CJC-1295 (no DAC) Compares

PeptideHalf-LifeRouteResearch Status
CJC-1295 (no DAC)No published PK data foundSubcutaneous injectionPreclinical (animal)
CJC-1295 (with DAC)6-8 daysSubcutaneous injectionPhase 1 / early human
GHRP-2No published PK data foundSubcutaneous injectionPhase 1 / early human
GHRP-6No published PK data foundSubcutaneous injectionPhase 1 / early human
HexarelinNo published PK data foundSubcutaneous injectionPhase 1 / early human

Values reflect figures reported in published research. Compare any peptides side-by-side →

Compare CJC-1295 (no DAC) with…

Frequently Asked Questions

What is CJC-1295 (no DAC)?
Modified Growth Hormone Releasing Factor (1-29), proposed to provide more stable GH release when combined with GHRPs (no primary study found). Also known as Mod GRF 1-29.
How does CJC-1295 (no DAC) work?
In plain terms: It is expected to prompt the pituitary gland to release growth hormone, based on similar compounds; it has not been studied directly. Proposed mechanism, inferred from related GHRH analogues (no published studies of this compound were found): a GHRH-receptor agonist expected to stimulate pituitary GH release. The related GHRH analogue sermorelin (GRF 1-29) stimulates GH secretion from the anterior pituitary (Prakash 1999).
What is the research status of CJC-1295 (no DAC)?
CJC-1295 (no DAC) is at the following stage in the published literature: Preclinical (animal). All information is for research and educational purposes only.
What is the half-life of CJC-1295 (no DAC)?
Reported half-life: No published PK data found.
How is CJC-1295 (no DAC) administered in research?
Reported administration route in the literature: Subcutaneous injection. This is not a recommendation for human use.

Quick Actions

Category

This peptide belongs to the Growth Hormone category. View All Growth Hormone Peptides

Related Peptides

  • CJC-1295 (with DAC) (CJC-DAC, Growth Hormone) — View Profile
  • GHRP-2 (GHRP2, Growth Hormone) — View Profile
  • GHRP-6 (GHRP6, Growth Hormone) — View Profile
  • Hexarelin (HEX, Growth Hormone) — View Profile

From Our Affiliated Clinic

Prefer physician oversight? See how 1836 Wellness works.

1836 Wellness is a physician-supervised clinic in Houston, TX. Discussing a compound on this page is not an offer to prescribe or supply it.

See how it works →

Disclosure: The Peptide Dispatch and 1836 Wellness are commonly owned by 1836 Wellness LLC. We may benefit financially if you become a client of 1836 Wellness. Learn more.

Sources & Methodology

Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.

← Back to Peptide Library Dosing Calculator The Dispatch Home