CJC-1295 without DAC (also known as Modified GRF 1-29 or Mod GRF) is a synthetic growth hormone-releasing hormone analog that lacks the Drug Affinity Complex modification. Without DAC, this peptide has a much shorter half-life of approximately 30 minutes, requiring more frequent administration but providing more precise control over GH release timing. The peptide contains the same amino acid modifications as CJC-1295 with DAC (substitutions at positions 2, 8, 15, 27, and 28) that prevent enzymatic degradation by dipeptidyl peptidase IV (DPP-IV). This version is often preferred by researchers who want to mimic natural pulsatile GH secretion more closely.
Key Data
Mechanism of Action
GHRH receptor agonist that stimulates pituitary to release GH in a pulsatile manner, synergizes with GHRPs.
Reported Benefits
All information is presented for Research Use Only (RUO). Not medical advice.