CJC-DAC

CJC-1295 (with DAC)

Growth Hormone Phase 1 / early human

CJC-1295 with Drug Affinity Complex that extends half-life dramatically, providing sustained GH elevation over days rather than hours.

Regulatory status (as of Sept 2026)

Not FDA-approved. Not among the peptides named in the 2026 PCAC actions.

See the FDA peptide regulatory tracker · Read our July 27, 2026 dispatch on the FDA PCAC peptide vote
Educational summary. Every effect described below is drawn from the cited published research and describes what was observed in research subjects — not a promise of results, a dose recommendation, or an endorsement for human use. Many peptides are not FDA-approved. Consult a licensed healthcare provider before making any health decision. Full disclaimer.

1 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content

TL;DR — CJC-1295 (with DAC) at a Glance

CJC-1295 (with DAC) is a compound with only early, small human studies so far. CJC-1295 with Drug Affinity Complex that extends half-life dramatically, providing sustained GH elevation over days rather than hours.

Half-life6-8 days
How it's given in studiesSubcutaneous injection
Research stagePhase 1 / early human
Dosing
Published research: Healthy adults aged 21-61: single subcutaneous ascending doses, then 2-3 weekly or biweekly subcutaneous doses
detailsHealthy adults aged 21-61: single s.c. ascending doses, then 2-3 weekly or biweekly s.c. doses. Best tolerated at 30 or 60 µg/kg (Teichman 2006). That is about 2-4 mg per dose for a 70 kg adult, given once, weekly or every 2 weeks, over 28-49 days.
Community-reportedCommunity-reported: 1–2 mg per week, subcutaneous injection

Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.

Where each point comes from: Clinicalhuman trials and FDA labels   Lab / animalrodent, cell and ex vivo studies   Community-reporteduser experience and commonly used protocols, not from clinical studies

How It Works

In plain terms: It is a long-acting version of the hormone that tells the pituitary to release growth hormone, so its effect lasts for days. GHRH analogue with a drug affinity complex (DAC) modification designed to bind albumin and prolong its action. In two placebo-controlled trials in healthy adults, single and repeated subcutaneous doses produced prolonged increases in GH and IGF-I (Teichman 2006).

Effects Reported in Research

How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.

  • ClinicalRaised GH 2-10-fold for ≥6 days and IGF-I 1.5-3-fold for 9-11 days in healthy adults (Teichman 2006)

What Users Report (Community, Not Clinical)

Commonly reported protocol

Community-reportedUsers have reported doses of 1–2 mg per week (subcutaneous injection). This is not a recommendation.

What users report

  • Community-reportedImproved body composition
  • Community-reportedEnhanced recovery

Side effects users report

  • Community-reportedWater retention
  • Community-reportedTingling
  • Community-reportedFlushing
  • Community-reportedPotential for constant GH elevation

Side effects reported in studies are listed separately below.

Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.

Side Effects and Safety Notes

  • ClinicalNo serious adverse reactions in the Teichman 2006 trials; tolerability was best at 30-60 µg/kg
  • Long-term human safety data are lacking

References

  1. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
    Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. The Journal of clinical endocrinology and metabolism. 2006. PMID: 16352683.
    Study type: Two randomized placebo-controlled ascending-dose trials, healthy adults.
    DOI: 10.1210/jc.2005-1536 · PubMed

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How CJC-1295 (with DAC) Compares

PeptideHalf-LifeRouteResearch Status
CJC-1295 (with DAC)6-8 daysSubcutaneous injectionPhase 1 / early human
CJC-1295 (no DAC)No published PK data foundSubcutaneous injectionPreclinical (animal)
GHRP-2No published PK data foundSubcutaneous injectionPhase 1 / early human
GHRP-6No published PK data foundSubcutaneous injectionPhase 1 / early human
HexarelinNo published PK data foundSubcutaneous injectionPhase 1 / early human

Values reflect figures reported in published research. Compare any peptides side-by-side →

Compare CJC-1295 (with DAC) with…

Frequently Asked Questions

What is CJC-1295 (with DAC)?
CJC-1295 with Drug Affinity Complex that extends half-life dramatically, providing sustained GH elevation over days rather than hours.
How does CJC-1295 (with DAC) work?
In plain terms: It is a long-acting version of the hormone that tells the pituitary to release growth hormone, so its effect lasts for days. GHRH analogue with a drug affinity complex (DAC) modification designed to bind albumin and prolong its action. In two placebo-controlled trials in healthy adults, single and repeated subcutaneous doses produced prolonged increases in GH and IGF-I (Teichman 2006).
What is the research status of CJC-1295 (with DAC)?
CJC-1295 (with DAC) is at the following stage in the published literature: Phase 1 / early human. All information is for research and educational purposes only.
What is the half-life of CJC-1295 (with DAC)?
Reported half-life: 6-8 days.
How is CJC-1295 (with DAC) administered in research?
Reported administration route in the literature: Subcutaneous injection. This is not a recommendation for human use.

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Category

This peptide belongs to the Growth Hormone category. View All Growth Hormone Peptides

Related Peptides

  • CJC-1295 (no DAC) (CJC, Growth Hormone) — View Profile
  • GHRP-2 (GHRP2, Growth Hormone) — View Profile
  • GHRP-6 (GHRP6, Growth Hormone) — View Profile
  • Hexarelin (HEX, Growth Hormone) — View Profile

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Sources & Methodology

Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.

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