EPIT
Also known as: Epithalon, AEDG
Synthetic tetrapeptide (Ala-Glu-Asp-Gly), also known as Epithalon or AEDG, based on the natural pineal peptide Epithalamin. In cultured human fetal fibroblasts it induced telomerase activity and telomere elongation (in vitro); a pineal peptide study in female CBA mice reported longer lifespan and lower spontaneous tumour incidence.
Regulatory status (as of Sept 2026)
Not FDA-approved. Removed from 503A Category 2 on April 15, 2026. PCAC recommended for the 503A Bulks List (advisory); awaiting FDA rulemaking; not lawfully compoundable under 503A as of Sept 17, 2026. PCAC vote: 7–4–1 (yes–no–abstain), July 24, 2026.
See the FDA peptide regulatory tracker · Read our July 27, 2026 dispatch on the FDA PCAC peptide vote6 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content
Epitalon is a compound studied only in animals and lab experiments so far. Synthetic tetrapeptide (Ala-Glu-Asp-Gly), also known as Epithalon or AEDG, based on the natural pineal peptide Epithalamin.
| Half-life | Not established in published research |
|---|---|
| How it's given in studies | Subcutaneous injection |
| Research stage | Preclinical (animal) |
| Dosing | Published research: No published human dosing detailsCell culture: Epithalon added to human fetal fibroblast cultures (telomerase induction, telomere elongation) and 0.1 mM in mouse oocyte culture medium. Animal: subcutaneous injection in female CBA mice from 6 months of age until death (lifespan study). No published human dosing.Community-reportedCommunity-reported: 5–10 mg daily, subcutaneous injection |
Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.
Where each point comes from: Clinicalhuman trials and FDA labels Lab / animalrodent, cell and ex vivo studies Community-reporteduser experience and commonly used protocols, not from clinical studies
In plain terms: It is thought to switch on telomerase, an enzyme linked to cell aging, based on lab and animal studies. Proposed to act by inducing telomerase activity (shown in cultured human fetal fibroblasts) and through pineal/melatonin regulation (reported for the related pineal extract Epithalamin in rats).
How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.
Community-reportedCommonly reported doses range from 5 to 10 mg daily (subcutaneous injection). This is not a recommendation.
Side effects reported in studies are listed separately below.
Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.
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| Peptide | Half-Life | Route | Research Status |
|---|---|---|---|
| Epitalon | Unknown | Subcutaneous injection | Preclinical (animal) |
| FOXO4-DRI | Unknown | Subcutaneous injection | Preclinical (animal) |
| GDF-11 | Unknown | Subcutaneous injection | Preclinical (animal) |
| Humanin | Unknown | Subcutaneous injection | Preclinical (animal) |
| Matrixyl (Palmitoyl Pentapeptide-4) | Topical (not systemically relevant) | Topical | Cosmetic/topical |
Values reflect figures reported in published research. Compare any peptides side-by-side →
This peptide belongs to the Anti-Aging category. View All Anti-Aging Peptides
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Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.