FOXO4-DRI (FOXO4)

FOXO4-DRI is a cell-penetrating peptide designed to selectively induce apoptosis (programmed cell death) in senescent cells while leaving healthy cells unaffected. The peptide works by disrupting the interaction between FOXO4 and p53, two proteins that normally work together to keep senescent cells in a state of suspended animation. In senescent cells, FOXO4 sequesters p53 in the nucleus, preventing apoptosis. FOXO4-DRI is a D-retro-inverso peptide version of the FOXO4 domain that binds p53, effectively competing with endogenous FOXO4 and releasing p53 to trigger apoptosis specifically in senescent cells. This senolytic approach represents a promising strategy for addressing age-related tissue dysfunction caused by accumulated senescent cells.

Key Data

Research Status

Early research

Half-Life

Unknown

Administration

Subcutaneous injection

Typical Dosage

Research varies

Molecular Weight

Approximately 4,500 Da (varies by specific construct)

Molecular Formula

Variable based on specific peptide length and modifications

Mechanism of Action

D-retro-inverso peptide that interferes with FOXO4-p53 binding in senescent cells, triggering their apoptosis.

Reported Benefits

• Senescent cell clearance
• Tissue rejuvenation
• Anti-aging potential
• Reduced inflammation

All information is presented for Research Use Only (RUO). Not medical advice.