SEL
Synthetic analog of the immunomodulatory peptide tuftsin, with anxiolytic-like effects reported in rodent models and limited human data. Developed alongside Semax in Russia.
Regulatory status (as of Sept 2026)
Not FDA-approved; not among the six peptides PCAC recommended for the 503A Bulks List in July 2026.
See the FDA peptide regulatory tracker · Read our July 27, 2026 dispatch on the FDA PCAC peptide vote4 studies referenced · Last reviewed Oct 1, 2026 · Reviewed by The Peptide Dispatch Editorial Team · How we research & label content
Selank is approved as a medicine in some countries outside the US, but not by the FDA. Synthetic analog of the immunomodulatory peptide tuftsin, with anxiolytic-like effects reported in rodent models and limited human data.
| Half-life | Not established in published research |
|---|---|
| How it's given in studies | Intranasal |
| Research stage | Approved outside US |
| Dosing | Published research: 0.3 mg/kg intraperitoneal (anxiolytic dose) in rats and mice details0.3 mg/kg i.p. (anxiolytic dose) in rats and mice; single injection in healthy human volunteers in an fMRI study (n=52, dose not in abstract)Community-reportedCommunity-reported: 250–500 mcg, intranasal |
Published-research dosing is what was given in the cited studies (species and units as reported). Community-reported dosing is what users describe, not from clinical studies. Neither is a recommendation. Not medical advice.
Where each point comes from: Clinicalhuman trials and FDA labels Lab / animalrodent, cell and ex vivo studies Community-reporteduser experience and commonly used protocols, not from clinical studies
In plain terms: It is a lab-made peptide thought to act on the brain's calming (GABA) system, based mostly on animal studies. Proposed mechanism, from animal studies and a review: a synthetic tuftsin analogue proposed to act on GABA-related systems (review, Doyno 2021). Anxiolytic-like effects were reported in rats (Kasian 2017); a human fMRI study (n=52 healthy volunteers) examined its effects on resting-state brain connectivity (Panikratova 2020).
How to read this: Each item below is an effect observed in research subjects in the cited studies — think of Dexter, our stand-in research subject. These are findings from the literature, not results you should expect, and not medical advice.
Community-reportedCommonly reported doses range from 250 to 500 mcg (intranasal). This is not a recommendation.
Side effects reported in studies are listed separately below.
Community reports are anecdotal, vary widely in product quality and purity, and are not medical advice. Talk to a licensed provider.
N-acetyl Selank is an acetylated form of Selank. No published studies of this modified form were found, and there is no evidence that it shares Selank’s pharmacology. Findings on this page are for Selank.
New research, FDA peptide updates, and what users are reporting. One email a week. Unsubscribe anytime.
| Peptide | Half-Life | Route | Research Status |
|---|---|---|---|
| Selank | No published PK data found | Intranasal | Approved outside US |
| Dihexa | Unknown | Oral or intraperitoneal (rodent studies only); no human administration published | Preclinical (animal) |
| FGL (L) | Unknown | Subcutaneous injection | Preclinical (animal) |
| P21 | Unknown | Oral (mice) | Preclinical (animal) |
| PE-22-28 | No published PK data found | Subcutaneous injection, Intranasal | Preclinical (animal) |
Values reflect figures reported in published research. Compare any peptides side-by-side →
This peptide belongs to the Cognitive category. View All Cognitive Peptides
Immune
From Our Affiliated Clinic
1836 Wellness is a physician-supervised clinic in Houston, TX. Discussing a compound on this page is not an offer to prescribe or supply it.
See how it works →Disclosure: The Peptide Dispatch and 1836 Wellness are commonly owned by 1836 Wellness LLC. We may benefit financially if you become a client of 1836 Wellness. Learn more.
Dosing, half-life figures, and mechanism descriptions on this page are compiled from peer-reviewed published research, with the species and study type stated where reported. Figures labeled “Dosing used in published research” describe what was given in those studies and do not constitute dosing recommendations for any human use. Each cited paper is listed with DOI and PubMed links in the References section above. Found an error? Contact us.