Sermorelin is a synthetic 29-amino acid peptide corresponding to the first 29 amino acids of naturally occurring human growth hormone-releasing hormone (GHRH 1-29). It was the first GHRH analog approved by the FDA for diagnostic and therapeutic use. Sermorelin stimulates the pituitary gland to produce and release growth hormone in a physiological, pulsatile manner. Unlike exogenous GH administration, Sermorelin preserves the natural feedback mechanisms that regulate GH secretion. This makes it suitable for long-term use without causing pituitary suppression. Sermorelin is used clinically for GH deficiency diagnosis and has been studied for anti-aging applications.
| Research Status | FDA approved (diagnostic) |
|---|---|
| Half-Life | 10-20 minutes |
| Administration | Subcutaneous injection |
| Typical Dosage | 100-300 mcg |
| Molecular Weight | 3,358 Da |
| Molecular Formula | C149H246N44O42S |
Natural GHRH fragment that stimulates pituitary GH release in a physiological pulsatile pattern.
All information is presented for Research Use Only (RUO). Not medical advice.