Triptorelin is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH/LHRH) with significantly greater potency and longer duration of action than natural GnRH. As a GnRH agonist, triptorelin initially causes a surge in LH, FSH, and sex hormones ("flare effect"), followed by downregulation of GnRH receptors and profound suppression of the reproductive axis with continuous administration. Triptorelin is FDA-approved for advanced prostate cancer, endometriosis, uterine fibroids, precocious puberty, and as part of fertility treatment protocols. Depot formulations allow once-monthly or every-3-month dosing.
Key Data
Mechanism of Action
Initial GnRH receptor stimulation followed by downregulation with continued use.
Reported Benefits
All information is presented for Research Use Only (RUO). Not medical advice.